Causal Inference Engine: a platform for directional gene set enrichment analysis and inference of active transcriptional regulators
نویسندگان
چکیده
منابع مشابه
A Causal Knowledge-Driven Inference Engine for Expert System
A wide variety of knowledge acquisition methods exist for conventional knowledge types such as production rule, semantic knowledge, etc. However, need for causal knowledge acquisition has not been stressed in the expert systems fields. The objectives of this paper are to (1) suggest a causal knowledge acquisition process and (2) investigate the causal knowledge-based inference process. FCM (Fuz...
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MOTIVATION Transcriptional regulatory networks specify the interactions among regulatory genes and between regulatory genes and their target genes. Discovering transcriptional regulatory networks helps us to understand the underlying mechanism of complex cellular processes and responses. METHOD This paper describes a causal inference approach for constructing transcriptional regulatory networ...
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For obtaining causal inferences that are objective, and therefore have the best chance of revealing scientific truths, carefully designed and executed randomized experiments are generally considered to be the gold standard. Observational studies, in contrast, are generally fraught with problems that compromise any claim for objectivity of the resulting causal inferences. The thesis here is that...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2019
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkz1046